[109.10.14]Imbalance-Effective Active Learning in Nucleus, Lymphocyte and Plasma Cell Detection


講 題:
Imbalance-Effective Active Learning in Nucleus, Lymphocyte and Plasma Cell Detection

Abstract. An Imbalance-Effective Active Learning (IEAL) based deep neural network algorithm is proposed for the automatic detection of nucleus, lymphocyte and plasma cells in hepatitis diagnosis. The active sampling approach reduces the training sample annotation cost and mitigates extreme imbalances among the nucleus, lymphocytes and plasma samples. A Bayesian U-net model is developed by incorporating IEAL with basic U-Net. The testing results obtained using an in-house dataset consisting of 43 whole slide images (300 256*256 images) show that the proposed method achieves an equal or better performance compared than a basic U-net classifier using less than half the number of annotated samples. 

Pau-Choo (Julia) Chung (S’89-M’91-SM’02-F’08) received the Ph.D. degree in electrical engineering from Texas Tech University, USA, in 1991. She then joined the Department of Electrical Engineering, National Cheng Kung University (NCKU), Taiwan, in 1991 and has become a full professor in 1996. She served as the Head of Department of Electrical Engineering (2011-2014), the Director of Institute of Computer and Communication Engineering (2008-2011), the Vice Dean of College of Electrical Engineering and Computer Science (2011), the Director of the Center for Research of E-life Digital Technology (2005-2008), and the Director of Electrical Laboratory (2005-2008), NCKU. She was elected Distinguished Professor of NCKU in 2005 and received the Distinguished Professor Award of Chinese Institute of Electrical Engineering in 2012. She also served as Program Director of Intelligent Computing Division, Ministry of Science and Technology (2012-2014), Taiwan. She was the Director General of the Department of Information and Technology Education, Ministry of Education (2016-2018). She served the Vice President for Members Activities, IEEE CIS (2015-2018). Currently she is the Director of Computing Center of NCKU and serves as the Chair of IEEE CIS Strategy Planning Committee.
Dr. Chung’s research interests include computational intelligence, medical image analysis, video analysis, and pattern recognition. Dr. Chung participated in many international conferences and society activities. She served as the program committee member in many international conferences. She served as the Publicity Co-Chair of WCCI 2014, SSCI 2013, SSCI 2011, and WCCI 2010. She served as an Associate Editor of IEEE Transactions on Neural Network and Learning Systems(2013-2015) and the Associate Editor of IEEE Transactions on Biomedical Circuits and Systems.

Dr. Chung was the Chair of IEEE Computational Intelligence Society (CIS) (2004-2005) in Tainan Chapter, the Chair of the IEEE Life Science Systems and Applications Technical Committee (2008-2009). She was a member in BoG of CAS Society (2007-2009, 2010-2012). She served as an IEEE CAS Society Distinguished Lecturer (2005-2007) and the Chair of CIS Distinguished Lecturer Program (2012-2013). She served on two terms of ADCOM member of IEEE CIS (2009-2011, 2012-2014), the Chair of IEEE CIS Women in CI (2014). She is a Member of Phi Tau Phi honor society and is an IEEE Fellow since 2008.